Short Communication Published: 30 Apr, 2018

Journal of Neurology Forecast We all have Alzheimer’s Disease: The Legacy of the 2018 National Institute on Aging’s Research Framework Toward a Biological Definition of Alzheimer’s Disease Mario D. Garrett* Department of Social Work, San Diego State University, California, USA

Short Communication In 2018, the National Institute on Aging and the Alzheimer’s Association (NIA-AA) in publishing a new “Framework” has reverted back to the original definition of Alzheimer’s disease [1]. A definition that relies solely on the presence of plaques and tangles as the signature of Alzheimer’s disease, while overall neurological damage defines the severity of the disease. The clinical aspect of the disease-what we think of as Alzheimer’s disease, by how it is expressed through loss of memory, changes in mental capacities and even mood and personality changes-is ignored. In contrast to an earlier definition [2] the disease is now defined solely by its biology. The Framework’s reliance on biology is however premature and flawed. In one study that looked at 2,332 brains of people that died from various causes, including children, only 10 brains showed a complete lack of plaques and tangles (less than half one percent) [3]. Everyone over the age of 24 years had plaques and tangles. By the Framework’s criteria, all older adults will automatically be diagnosed with Alzheimer’s disease. Even the authors admit that there are high false positives. “Up to 60% of CU [cognitive unimpaired/normal] individuals over age 80 years have AD [Alzheimer’s disease] neuropathologic changes at autopsy or by biomarkers.” (p.552) [1]. Fifty percent false positives does not form a solid foundation to develop a diagnostic tool based purely on biomarkers.


Correspondence: Mario D. Garrett, Department of Social Work, San Diego State University, California, USA. E-mail: [email protected] Received Date: 11 Mar 2017 Accepted Date: 25 Apr 2018 Published Date: 30 Apr 2018 Citation: Garrett MD. We all have Alzheimer’s Disease: The Legacy of the 2018 National Institute on Aging’s Research Framework Toward a Biological Definition of Alzheimer’s Disease. J Neurol Forecast. 2018; 1(1): 1003.

These are the same odds as a coin toss. Except that a diagnosis of Alzheimer’s disease will definitely influence a judge’s determination of your capacity and might result in a change in your legal status, managing your affairs, driving a car and piloting an airplane, entering into a contract, inheritance, and even custody [4]. Because of similar conflicts of interest, a French court in 2009 withdrew such guidelines for Alzheimer’s disease as they contravened national law [5].

References 1. Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Elliott CL, et al. 2017 Nia-Aa Research Framework to Investigate the Alzheimer’s Disease Continuum. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2017; 13: P890-891. 2. Jack CR, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2011; 7: 257-262. 3. Braak H, Thal DR, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. Journal of Neuropathology & Experimental Neurology. 2011; 70: 960-969. 4. Hegde S, Ellajosyula R. Capacity issues and decision-making in dementia. Annals of Indian Academy of Neurology. 2016; 19: S34. 5. Garrett MD. A Critique of the 2018 National Institute on Aging’s. Research Framework: Toward a biological definition of Alzheimer’s disease. Curr Neuro biol. 2018; 9: 49-58.

Copyright © 2018 Mario D. Garrett. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

ScienceForecast Publications LLC., |

1 1

2018 | Volume 1 | Edition 1 | Article 1003

We all have Alzheimer's Disease: The Legacy of the ...

Apr 30, 2018 - a Biological Definition of Alzheimer's Disease ... we think of as Alzheimer's disease, by how it is expressed through loss of memory, changes in ...

356KB Sizes 2 Downloads 158 Views

Recommend Documents Have Tripled The Number Of ...
Page 2 of 3. 9. Gymboree: 350 stores. 10. HHgregg: 220 stores. 11. J.Crew: 50 stores. 12. JC Penney: 138 stores ... Page 3 of 3. 3/3. Page 3 of 3. Main menu. Displaying Have Tripled The Number Of Store Closings From Las

pdf-0944\dementia-alzheimers-disease-stages-treatments-and ...
... variant kinds of publications. Page 3 of 7. pdf-0944\dementia-alzheimers-disease-stages-treatme ... s-alzheimers-roadmap-by-laura-town-karen-kassel.pdf.

Download All We Have Left Full Online
When you buy an al or a song, you can also download it on Android, Windows 10, Windows 8 and Windows Phone 8. All We ... Nine, Ten: A September 11 Story.

[PDF] Download All We Have Left
Aug 15, 2017 - ... be seeing how to download PDF documents from Scribd without having an account ... Simply Sign Up to one of our plans and start browsing.

Lunarbaboon-Presents-We-All-Have-Powers-And ...
... on the internet electronic digital library which offers access to many PDF guide .... hrs in the past I don't check out this to be a shortcoming both, as a faucet ... YOU CAN\'T TOUCH MY HAIR: AND OTHER THINGS I STILL HAVE TO EXPLAIN.

[PDF] Download All We Have Left - Free Download ...
... you reGlenn Harrold Learn How To Think Positively Download PDF MOBi EPUB ... and remove the Adobe DRM from acsm file to be read on various devices.

[PDF] Download All We Have Left Read Online
... Apk 2017 official Mobdro app for PC Laptop Windows Android Kindle iOS iPhone iPad Mac Kodi Smart ... Publisher : Bloomsbury USA Childrens 2016-08-09.

PRIVACY POLICY. We have adopted the ... Accounts
Generate analytics that improve the Site layout, content and offerings ... user data that is stored in Our database (directly or through Our business partners.