Short Communication Published: 30 Apr, 2018

Journal of Neurology Forecast We all have Alzheimer’s Disease: The Legacy of the 2018 National Institute on Aging’s Research Framework Toward a Biological Definition of Alzheimer’s Disease Mario D. Garrett* Department of Social Work, San Diego State University, California, USA

Short Communication In 2018, the National Institute on Aging and the Alzheimer’s Association (NIA-AA) in publishing a new “Framework” has reverted back to the original definition of Alzheimer’s disease [1]. A definition that relies solely on the presence of plaques and tangles as the signature of Alzheimer’s disease, while overall neurological damage defines the severity of the disease. The clinical aspect of the disease-what we think of as Alzheimer’s disease, by how it is expressed through loss of memory, changes in mental capacities and even mood and personality changes-is ignored. In contrast to an earlier definition [2] the disease is now defined solely by its biology. The Framework’s reliance on biology is however premature and flawed. In one study that looked at 2,332 brains of people that died from various causes, including children, only 10 brains showed a complete lack of plaques and tangles (less than half one percent) [3]. Everyone over the age of 24 years had plaques and tangles. By the Framework’s criteria, all older adults will automatically be diagnosed with Alzheimer’s disease. Even the authors admit that there are high false positives. “Up to 60% of CU [cognitive unimpaired/normal] individuals over age 80 years have AD [Alzheimer’s disease] neuropathologic changes at autopsy or by biomarkers.” (p.552) [1]. Fifty percent false positives does not form a solid foundation to develop a diagnostic tool based purely on biomarkers.

OPEN ACCESS *

Correspondence: Mario D. Garrett, Department of Social Work, San Diego State University, California, USA. E-mail: [email protected] Received Date: 11 Mar 2017 Accepted Date: 25 Apr 2018 Published Date: 30 Apr 2018 Citation: Garrett MD. We all have Alzheimer’s Disease: The Legacy of the 2018 National Institute on Aging’s Research Framework Toward a Biological Definition of Alzheimer’s Disease. J Neurol Forecast. 2018; 1(1): 1003.

These are the same odds as a coin toss. Except that a diagnosis of Alzheimer’s disease will definitely influence a judge’s determination of your capacity and might result in a change in your legal status, managing your affairs, driving a car and piloting an airplane, entering into a contract, inheritance, and even custody [4]. Because of similar conflicts of interest, a French court in 2009 withdrew such guidelines for Alzheimer’s disease as they contravened national law [5].

References 1. Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Elliott CL, et al. 2017 Nia-Aa Research Framework to Investigate the Alzheimer’s Disease Continuum. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2017; 13: P890-891. 2. Jack CR, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2011; 7: 257-262. 3. Braak H, Thal DR, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. Journal of Neuropathology & Experimental Neurology. 2011; 70: 960-969. 4. Hegde S, Ellajosyula R. Capacity issues and decision-making in dementia. Annals of Indian Academy of Neurology. 2016; 19: S34. 5. Garrett MD. A Critique of the 2018 National Institute on Aging’s. Research Framework: Toward a biological definition of Alzheimer’s disease. Curr Neuro biol. 2018; 9: 49-58.

Copyright © 2018 Mario D. Garrett. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

ScienceForecast Publications LLC., | https://scienceforecastoa.com/

1 1

2018 | Volume 1 | Edition 1 | Article 1003

We all have Alzheimer's Disease: The Legacy of the ...

Apr 30, 2018 - a Biological Definition of Alzheimer's Disease ... we think of as Alzheimer's disease, by how it is expressed through loss of memory, changes in ...

356KB Sizes 0 Downloads 40 Views

Recommend Documents

theeconomiccollapseblog.com-We Have Tripled The Number Of ...
Page 2 of 3. 9. Gymboree: 350 stores. 10. HHgregg: 220 stores. 11. J.Crew: 50 stores. 12. JC Penney: 138 stores ... Page 3 of 3. 3/3. Page 3 of 3. Main menu. Displaying theeconomiccollapseblog.com-We Have Tripled The Number Of Store Closings From Las

Early Diagnosis of Alzheimers Disease and Features ...
a population of patients by considering different sets of features. To this aim, in this project we test two of the top 10 algorithms in Machine Learning [1], i.e., Multilayer. Perceptron (MLP) and Naive Bayes, to predict the presence of Alzheimer di

pdf-0944\dementia-alzheimers-disease-stages-treatments-and ...
... variant kinds of publications. Page 3 of 7. pdf-0944\dementia-alzheimers-disease-stages-treatme ... s-alzheimers-roadmap-by-laura-town-karen-kassel.pdf.

theeconomiccollapseblog.com-We Have Tripled The Number Of Store ...
27 Nov 2017 - Page 1 of 3. We Have Tripled The Number Of Store Closings From Last. Year, And 20 Major Retailers Have Closed At Least 50 Stores. In 2017. theeconomiccollapseblog.com/archives/we-have-tripled-the-number-of-store-closings-from-last-year-

Download All We Have Left Full Online
When you buy an al or a song, you can also download it on Android, Windows 10, Windows 8 and Windows Phone 8. All We ... Nine, Ten: A September 11 Story.

[PDF] Download All We Have Left Full Audiobook
... Crosswords for 50 only BUY NOW 50 DollarsView and Download Apple IPHONE SE user manual online IPHONE SE Cell Phone pdf manual download Hyde ...

[PDF] Download All We Have Left Pdf
... sharing and storage 15 GB free web space Easy registration File upload progressor Multiple file transfer Fast download Free go kart plans Download a PDF of ...

[PDF] Download All We Have Left - Free Download ...
... you reGlenn Harrold Learn How To Think Positively Download PDF MOBi EPUB ... and remove the Adobe DRM from acsm file to be read on various devices.

[PDF] Download All We Have Left Read Online
... Apk 2017 official Mobdro app for PC Laptop Windows Android Kindle iOS iPhone iPad Mac Kodi Smart ... Publisher : Bloomsbury USA Childrens 2016-08-09.

[PDF] Download All We Have Left Read Online
... account required Online file sharing and storage 15 GB free web space Easy ... Server at unep org Port 80 Download a PDF of free go kart plans and see my ...

eBook Download All We Have Left - (PDF Download ...
... Online Store Builder ETS Store eBook Help Customer Service Find answers to ... master artistic blacksmithing From Nitro PDF Software Use PDF Download to do ... Read Online All We Have Left Wendy Mills E-Books, Download Best Book ...

Full Book PDF All We Have Left
... as many audiobooks ebooks So for the price everyone else charges for just 1 ... To Read Ebook Download our app to read books Download the Scribd app for ...

[PDF] Download All We Have Left
Aug 15, 2017 - ... be seeing how to download PDF documents from Scribd without having an account ... Simply Sign Up to one of our plans and start browsing.

[PDF] Download All We Have Left Pages Full
Download free apps about PC games for Windows All Quiet on the Western Front full of beef and haricot beans We are satisfied and at peace We have not had ...

Lunarbaboon-Presents-We-All-Have-Powers-And ...
... on the internet electronic digital library which offers access to many PDF guide .... hrs in the past I don't check out this to be a shortcoming both, as a faucet ... YOU CAN\'T TOUCH MY HAIR: AND OTHER THINGS I STILL HAVE TO EXPLAIN.

[PDF] All We Have Left Read Book
dad since has filled their home with anger and grief. ... Are you looking for free ebook download sites Or interested to download ePub books on internet We ... up to 100MB and premium services I’ve been both a student and an instructor ...

[PDF] Download All We Have Left Pages Full
[PDF] Download All We Have Left Pages Full ... won’t allow us Free PDF Printer Create PDF documents from Windows applications ... 8 Windows Server 2012 Windows 7 Vista 2008R2 2008 FLVS Florida Virtual School is an ... Verification download the

All We Have Left by Wendy Mills
Read and Download Ebook All We Have Left PDF. [Free Download] All We Have Left PDF by Wendy ... Interweaving stories from past and present, All We Have Left brings one of the most important days in our recent history to life, showing that love ... la

The Legacy of Ocala Stud
Call it a milestone purchase in Florida thoroughbred history. On. Jan. 16, 1956, Maryland ... Needles was named the 1956 champion 3-year-old male, the spotlight shone brightly on ... And Florida was on its way to becoming the country's prime ...

The Problem We All Face.pdf
Why did Rockwell choose to dress Ruby Bridges in all white? (note that in the original. press photograph, she was wearing a plaid dress and black shoes). 8. Why don't we see the Marshal's heads? 9. Why did Rockwell choose to paint the words on the wa

Read PDF We Have the Technology: How Biohackers ...
... S 50 Knife Shop Revised We Are Never Meeting In Real Life Essays We … ... One Sense at a Time Free Online, Free Download We Have the Technology: ...

Do We Have the Holy Ghost.pdf
Page 1 of 1. When You Have the Spirit. ○You generally feel happy and calm. ○ You feel full of light. ○ Your mind is clear. ○ You feel love for the Lord and others. ○ You feel generous. ○ Nobody can offend you. ○ You are very forgiving a

PRIVACY POLICY. We have adopted the ... Accounts
Generate analytics that improve the Site layout, content and offerings ... user data that is stored in Our database (directly or through Our business partners.

We-ll-Always-Have-Summer-The-Summer-I-Turned-Pretty.pdf
Download ]]]]]>>>>>[EPub] We\'ll Always Have Summer (The Summer I Turned Pretty). (PDF) We'll Always Have Summer (The Summer I Turned. Pretty). WE'LL ALWAYS HAVE SUMMER (THE SUMMER I TURNED PRETTY) EBOOK AUTHOR BY JENNY. HAN. We'll Always Have Summer