Four SICA project meeting Imperial College, London, 24 May 2013

Genetic and environmental factors of Metabolic Syndrome in Mediterranean populations Florin Grigorescu MD, PhD (France)

1

Modern migrations (immigrants) MEDIGENE populations Albanese (Illyrians), Turkish (Altaic populations with Central Asians components), Romanian (Geto-Thracic populations from the Carpato-Danubian basin), North African immigrants (Berbers admixed with Bedouin tribes or Canaanite-Phoenicians in historical times) - Algerians, Tunisians and Moroccans.

2

Relationship between migration and health Vulnerable populations

Statistically immortal Selection theory

Epi-genetics Contact 1st Gen

Home

Salmon theory

Genetic background ?

Host (Natives) 2nd Gen

Epidemiological paradoxes

Refugee Age of migration

Acculturation Life style

Stress

3

Working packages WP1 1st STAGE GWAS 600 000 SNPs

Available DNA

WP2 Ancient DNA study In historical Romans Ancient DNA

WP3 Locus refining •

••••••••••••



WP4 1st STAGE analysis CC association in host countries Filtered SNPs

New DNA sampling

WP5 Epidemiology in host and home countries & novel recruitment for G x E interaction Rare SNPs WP6 2nd STAGE - Replication Genotyping with filtered SNPs

WP7 2nd stage analysis and meta-analysis

Replication

WP8 Replication in Home countries

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Consortium

Clinical endocrinologists and geneticists, anthropologists, demographist & archaeologists Florin Grigorescu (CO), Michel Pugeat, Ramon Gomis, Josep M. M acias, Mihai Coculescu, Renato Pasquali, Giorgio Sesti, Vincenzo Trischitta, Davide Lauro, Agathocles Tsatsoulis, Elza Khusnutdinova, Sonia Abdelhak, Akila Zenati, Abdelhamid Barakat, IIly Agron, Timo Kanninen, Robert Hermann, Ilhan Satman Rhône Alpes

Coordination Montpellier 3

Moldova 5 Bologna 1

Taragona Barcelona

CIBERDEM 2

Casablanca

IPM 14

13

Alger

Oufa IBG 10

Tirana Bucharest 4 15 Rome 7, 8 Istambul Cantazaro 9 11 6 Ioannina

IPT Tunis 12

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Four SICA project meeting. Imperial College, London, 24 May 2013. Florin Grigorescu MD, PhD ... Consortium. Taragona. Cantazaro. Rome. Bologna. Bucharest.

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