PDF Next-Generation DNA Sequencing Informatics, Second Edition Full Books Books detail ●
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Title : PDF Next-Generation DNA Sequencing Informatics, Second Edition Full Books isbn : 1621821234
Book synopsis Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making genome and RNA sequencing an affordable and frequently used tool for a wide variety of research applications including variant (mutation) discovery, gene expression, transcription factor analysis, metagenomics, and epigenetics. Bioinformatics methods to support DNA sequencing have become and remain a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. This new edition provides a thorough, plain-language introduction to the necessary informatics methods and tools for analyzing NGS data and provides detailed descriptions of algorithms, strengths and weaknesses of specific tools, pitfalls, and alternative methods. Four new chapters cover experimental design, sample preparation, and quality assessment of NGS data; public databases for DNA sequencing data; de novo transcript assembly; proteogenomics; and emerging sequencing technologies. The remaining chapters from the first edition have been updated with the latest information. This book also provides extensive reference to best-practice bioinformatics methods for NGS applications and tutorials for common workflows. This edition addresses the informatics needs of students, laboratory scientists, and computing specialists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies. Authors Alexander AlekseyenkoSilvia ArgimonBrian D. AtheyMiroslav BlumenbergStuart M. BrownLisa CohenEfstratios EfstathiadisDavid FenyoJeremy GoecksGerald A. HigginsD. Frank HsuKranti KongantiKonstantinos KrampisGuillermo I. Perez-PerezKelly V. Ruggles Christina SchweikertSteven ShenPhillip Ross SmithZuojian TangJinhua Wang"
Related Bioinformatics Algorithms: An Active Learning Approach
PDF Next-Generation DNA Sequencing Informatics ...
and RNA sequencing an affordable and frequently used tool for a wide variety of ... to the necessary informatics methods and tools for analyzing NGS data and.
times smaller than genomes and are therefore 10â100 ..... 50â100 μL of DNAse-free water depending on pellet size. Complete DNA ..... nine rich domain.
Aug 3, 2010 - NGSTs can be applied to various domains of plant biology, and we identify ...... SNP and InDel markers will be affordable for most crops, thus.
Jun 24, 2008 - selected pieces of approximately 2â3 kb. These pieces are ... Three platforms for massively parallel DNA ... and uses an alternative sequencing technology ...... gut microbiome with increased capacity for energy harvest.
available to many more researchers and projects. However, while ... standing of the technologies available; including sources of error, error rate, as well as the ...... ogy [14] and, recently, IBM's proposal of .... This may open the market further
Jun 24, 2008 - Furthermore, next-generation platforms are helping to open ... DNA source of interest. Because ..... new algorithms and data visualization inter-.
Aug 3, 2010 - A popular solution with classical sequenc- ... This information is archived in sev- ..... The Arabidopsis genome annotation is archived on TAIR ...... [24] L.D. Stein, The case for cloud computing in genome informatics, Genome ...
Aug 11, 2006 - bases on specially designed templates (2), and ... DNA template. Tran- .... E-mail: [email protected]. Fig. 1. Motion-based DNA sequencing.
Receive free email alerts when new articles cite this article - sign up in the box at the. Notes .... E-MAIL [email protected]; FAX (650) 812-1975. Article and ...
The large amount of DNA sequence data generated by high-throughput sequencing technologies ..... To avoid a downstream failure of Illumina's image analysis software, subsets of indexes must be .... Max-Planck-Society for financial support.
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monadic DSL on top of the well-established ... DNA programs are composed of actors and channels. ... actors in a group, they get assigned ranks from 0 to N-1. ... For maintaing a robust system performance, we track the performance of all ...
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