WARF:P04164US

Method to Protect DNA Ends The bacterium Deinococcus radiodurans is the most radiation resistant organism known. D. radiodurans suffers many mutations and double-strand breaks during exposure to radiation, but is extraordinarily efficient at repairing its DNA. This invention provides a method of using a protein from D. radiodurans to protect the 3-prime end of a DNA molecule from damage by nucleases. The inventors identified five D. radiodurans genes that were very highly expressed following exposure to ionizing radiation. One of these genes, DR0423, produces a protein, DdrA (DNA damage response protein A), which binds to the 3-prime ends of single-stranded DNA and protects those ends from degradation by nucleases.

• Useful to “cap” free 3-prime ends of DNA to protect them during DNA processing • Useful in protocols requiring the generation of single-stranded, 3-prime extensions on duplex DNA

Patent applied for.

Michael M. Cox, Dennis R. Harris, Sergei V. Saveliev, John R. Battista, Edmond Jolivet, Masashi Tanaka, Julie M. Eggington

Phone: (608) 262-8638 / Email: [email protected]

Method to Protect DNA Ends

The bacterium Deinococcus radiodurans is the most radiation resistant organism known. D. radiodurans suffers many mutations and double-strand breaks ...
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