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Michael Peleg ‫מאת‬: ‫אל‬: ‫נשלח‬: ‫נושא‬:

"Michael Peleg (S)" 09:20 2007 ‫ יוני‬07 ‫יום חמישי‬ Biochem J (2007) Immediate Publication - J. Friedman et al..htm

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Biochem. J. (2007) Immediate Publication, doi:10.1042/BJ20061653

Chair G Banting Bristol

Mechanism of a short-term ERK activation by electromagnetic fields at mobile phone frequency

Vice Chair, The Americas G Salvesen - La Jolla, CA

Joseph Friedman, Sarah Kraus, Yirmi Hauptman, Yoni Schiff and Rony Seger

Reviews Editor A Toker Boston, MA

The exposure to non-thermal microwave electromagnetic field generated by mobile phones affects the expression of many proteins. This effect on transcription and protein stability can be mediated by the mitogen-activated protein kinase (MAPK) cascades, which serve as central signaling pathways, and govern essentially all stimulated cellular processes. Indeed, a longterm exposure of cells to mobile phone irradiation results in the activation of p38MAPKs as well as the ERK/MAPKs. Here we studied the immediate effect of irradiation on the MAPK cascades, and found that ERKs, but not stress related MAPKs are rapidly activated in response to various frequencies and intensities. Using signaling inhibitors we delineated the mechanism that is involved in this activation. We found that the first step is mediated in the plasma membrane by NADH oxidase, which rapidly generates reactive oxygen species (ROS). These ROS then directly stimulate matrix metalloproteinases and allow them to cleave and release heparin binding-EGF. This secreted factor, activates EGF receptor, which in turn further activates the ERK cascade. Thus, this study demonstrates for the first time a detailed molecular mechanism by which electromagnetic irradiation by mobile phones induces the activation of the ERK cascade and thereby induces transcription and other cellular processes.

Deputy Chairs DR Alessi Dundee C MacKintosh Dundee PR Shepherd Auckland MP Walsh Calgary Editors J Arino Barcelona J Blank Cambridge, MA M Bogoyevitch Melbourne B Brune Frankfurt D Carling London G Cote Kingston, Ont. J Couchman London V Darley-Usmar - Birmingham, AL R Docampo Athens, GA D Doyle - Oxford B Foxwell London D Gillespie -

Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel. [email protected]

doi:10.1042/BJ20061653 Received 3 November 2006/23 April 2007; Accepted 25 April 2007 Published as Immediate Publication 25 April 2007

09/06/2007

Banner image cou Kingston, Ont.

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Glasgow R Golsteyn Crossy-sur-Seine S Goodbourn London L Goodyear Boston, MA B Hallberg Umea B Holland Orsay J Hsuan London DA Jans Monash M Kazanietz Philadelphia, PA M Lemmon Philadelphia, PA D Litchfield London, Ont. L Machesky Birmingham E Manser Singapore P Maurel Montpellier M Noble - Oxford G Panayotou Vari M Parenti Monza S Patel - London M Schwartz Charlottesville, VA S Sealfon - New York, NY G.L Semenza Baltimore A Sim Callaghan, NSW E Smythe Sheffield S Spiegel Richmond, VA C Taylor Cambridge M Torti - Pavia C Troy - New York, NY D van Aalten Dundee B Vanhaesebroeck - London S Ward - Bath M Welham - Bath J York - Durham, NC I Zachary London Editorial Advisory Panel

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Mechanism of a short-term ERK activation by electromagnetic fields at ...

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