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Abstract. We report the synthesis of three new conjugates between a cRGD integrin ligand and alendronic acid as a bisphosphonate anchor. The selected ligand is an RGD peptidomimetic, carrying the conformationally constrained RGD sequence on an azabic
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g, 13.8 mmol) was dissolved in dry toluene (20 mL) and potassium hydroxide (9.60 g, powder) was added. The mixture was heated to reflux, and benzyl chloride (14.5 mL) was added dropwise. The reaction mixture was heated under reflux for 2.5 h and cool
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The products have been characterized on the basis of satisfactory analytical and spectral (IR, NMR, MS) data, and the mechanism of their formation is proposed.